منابع مشابه
SnapShot: Nuclear Receptors I
Estrogen receptors* ERα/NR3A1; ERβ/NR3A2 Endogenous: 17β-estradiol Regulation of cell growth and proliferation in multiple tissues (e.g., female reproductive tissues, bone, and CNS) Cancer, cardiovascular, immune and inflammatory, metabolic, neurological, reproductive ↑ MYC, NGF, BCL2, CXCL2, IGF1, TYMS; ↓ CD36, NDRG1, NCOR1, NCOA3 Clinical: Mixed agonists (e.g. tamoxifen, raloxifene, and torem...
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Snapshot’ research is a new multicenter study method which is particularly suited to investigate a common condition or treatment. These (mostly observational) studies are primarily initiated and conducted by trainees. Because of a good research network of these trainees, a large amount of data can be collected in a short period while the workload for each participating hospital remains limited....
متن کاملSnapShot: Cytokines I
IL-10 IL10R1 and IL10R2 Differentiated T helper cells, Tregs, B cells, dendritic cells, others Macrophages, T cells, dendritic cells, B cells Immune suppression; decreases antigen presentation and MHC class II expression of dendritic cells; downregulates pathogenic Th1, Th2, and Th17 responses ↓ = immune pathology due to uncontrolled inflammation. ↑ = inhibits sterile immunity to some pathogens.
متن کاملSnapShot: Actin Regulators I
Protein Family Biochemical Function Representative Proteins H. sapiens D. melanogaster C. elegans A. thaliana S. cerevisiae Actin Nucleators Formins associates with barbed ends, promotes nucleation Spir nucleates unbranched fi laments Spir-1, Spir-2 Spir/spire Arp2/3 complex polymerizes Y-branched fi lament networks ARP2,
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2015
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2015.05.001